Publications
2024
Y. Fernández-Afonso, L. Asín, J. Pardo, R. M. Fratila, S. Veintemillas, M. Puerto Morales and L. Gutiérrez - Key factors influencing magnetic nanoparticle-based photothermal therapy: physicochemical properties, irradiation power, and particle concentration in vitro, Nanoscale Adv., 2024, 7, 336
https://doi.org/10.1039/D4NA00384E
Y. Fernández-Afonso, S. Ruta, A. Páez-Rodríguez, T. S. van Zanten, S. Gleadhall, R. M. Fratila, M. Moros, M. Puerto Morales, A. Satoh, R. W. Chantrell, D. Serantes, L. Gutiérrez- Reversible Alignment of Nanoparticles and Intracellular Vesicles During Magnetic Hyperthermia Experiments, Advanced Functional Materials, 2024, 34, 2405334
https://advanced.onlinelibrary.wiley.com/doi/10.1002/adfm.202405334
J. Idiago-López, D. Pereira, L. Asín, M. Moros, I. Armenia, V. Grazú, A. R. Fernandes, J. M. de la Fuente, P. V. Baptista and R. M. Fratila* - Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes, Nanoscale, 2024, 16, 15176
https://doi.org/10.1039/D4NR01955E
2023
C. Castro-Hinojosa, S. Del Sol-Fernández, E. Moreno-Antolín, B. Martín-Gracia, J. G. Ovejero, J. M. de la Fuente, V. Grazú, R. M. Fratila*, M. Moros - A Simple and Versatile Strategy for Oriented Immobilization of His-Tagged Proteins on Magnetic Nanoparticles, Bioconj. Chemistry, 2023, 34, 2275
https://doi.org/10.1021/acs.bioconjchem.3c00417
2022
https://doi.org/10.1039/D1NR06303K
J. Idiago-López, E. Moreno-Antolín, M. Eceiza, J. M. Aizpurua, V. Grazú, J. M. de la Fuente and R. M. Fratila* - From Bench to Cell: A Roadmap for Assessing the Bioorthogonal “Click” Reactivity of Magnetic Nanoparticles for Cell Surface Engineering, Bioconj. Chemistry, 2022, 33, 1620
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.2c00230
Y. Fernández-Afonso, L. Asín, L. Beola, R. M. Fratila*, L. Gutiérrez - Influence of Magnetic Nanoparticle Degradation in the Frame of Magnetic Hyperthermia and Photothermal Treatments, ACS Appl. Nano Mater, 2022, 5, 16220
https://pubs.acs.org/doi/10.1021/acsanm.2c03220
Y. Fernández-Afonso, L. Asín, L. Beola, M. Moros, J. M. de la Fuente, R. M. Fratila, V. Grazu, L. Gutiérrez - Iron Speciation in Animal Tissues Using AC Magnetic Susceptibility Measurements: Quantification of Magnetic Nanoparticles, Ferritin, and Other Iron-Containing Species, ACS Appl. Bio Mater, 2022, 5, 1879
https://pubs.acs.org/doi/abs/10.1021/acsabm.1c01200
2021
L. Beola, V. Grazú, Y. Fernández-Afonso, R. M. Fratila, M. de las Heras, J. M. de la Fuente, L. Gutiérrez, L. Asín - Critical Parameters to Improve Pancreatic Cancer Treatment Using Magnetic Hyperthermia: Field Conditions, Immune Response, and Particle Biodistribution, ACS Appl. Mater. Interfaces, 2021, 13, 12982
https://pubs.acs.org/doi/10.1021/acsami.1c02338
http://pubs.acs.org/articlesonrequest/AOR-67TDKKDGJGABCADUIEDA
B. Pem, M. Ćurlin, D. Domazet Jurašin, V. Vrček, R. Barbir, V. Micek, R. M. Fratila, J. M. de la Fuente, I. Vinković Vrček - Fate and Transformation of Silver Nanoparticles in Different Biological Conditions, Beilstein J. Nanotechnol. 2021, 12, 665
https://doi.org/10.3762/bjnano.12.53
J. Idiago-López, E. Moreno-Antolín, J. M. de la Fuente and R. M. Fratila* - Nanoparticles and bioorthogonal chemistry joining forces for improved biomedical applications, Nanoscale Adv., 2021, 3, 1261
https://pubs.rsc.org/en/content/articlelanding/2021/na/d0na00873g#!divAbstract
S. Hildebrand, N. Löwa, H. Paysen, R. M. Fratila, L. Reverte Salisa, T. Trakoolwilaiwan, Z. Niu, G. Kasparis, S. F. Preuss, O. Kosch, J. M. de la Fuente, N. T. K. Thanh, F. Wiekhorst, and A. Pfeifer - Quantification of Lipoprotein Uptake in Vivo Using Magnetic Particle Imaging and Spectroscopy, ACS Nano, 2021, 15, 434
https://doi.org/10.1021/acsnano.0c03229
http://pubs.acs.org/articlesonrequest/AOR-GHCRGYCIFNXTP54NC9G4
2020
L. Beola, L. Asín, C. Roma-Rodrigues, Y. Fernández-Afonso, R. M. Fratila, D. Serantes, S. Ruta, R. Chantrell, A. R. Fernandes, P. V. Baptista, J. M. De La Fuente, V. Grazu, L. Gutiérrez - Intracellular number of magnetic nanoparticles modulates the apoptotic death pathway after magnetic hyperthermia treatment, ACS Appl. Mater. Interfaces, 2020,12, 43474
https://pubs.acs.org/doi/10.1021/acsami.0c12900
S. Ruiz - Rincón, A. González - Orive, V. Grazú, R. M. Fratila*, J. M. de la Fuente, P. Cea - Altering model cell membranes by means of localized magnetic heating, Coll. Surf. B: Biointerfaces, 2020, 196, 111315
https://doi.org/10.1016/j.colsurfb.2020.111315
2019
M. Moros, J. Idiago-López, L. Asín, E. Moreno-Antolín, L. Beola, V. Grazú, R. M. Fratila*, L. Gutiérrez, J. M. de la Fuente - Triggering antitumoural drug release and gene expression by magnetic hyperthermia, Adv. Drug Deliv. Rev., 2019, 138, 326
https://www.sciencedirect.com/science/article/pii/S0169409X18302527?via%3Dihub
2018
L. Beola, L. Asín, R. M. Fratila, V, Herrero, J. M. de la Fuente, V. Grazú, and L. Gutiérrez - Dual Role of Magnetic Nanoparticles as Intracellular Hotspots and Extracellular Matrix Disruptors Triggered by Magnetic Hyperthermia in 3D Cell Culture Models, ACS Appl. Mater. Interfaces, 2018, 10, 44301
https://pubs.acs.org/doi/10.1021/acsami.8b18270
O. K. Arriortua, M. Insausti, L. Lezama, I. Gil de Muro, E. Garaio, J. M. de la Fuente, R. M. Fratila, M. P. Morales, R. Costa, M. Eceiza, M.Sagartzazu-Aizpurua, J. M. Aizpurua - RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia, Coll. Surf. B: Biointerfaces, 2018, 165, 315
https://www.sciencedirect.com/science/article/abs/pii/S0927776518301061?via%3Dihub
P. Sanguiñedo, R. M. Fratila, M. B. Estevez, J. M. de la Fuente, V. Grazú, S. Alborés - Extracellular Biosynthesis of Silver Nanoparticles Using Fungi and Their Antibacterial Activity, Nano Biomed. Eng., 2018, 10, 165
http://nanobe.org/Data/View/502?type=100
G. Stepien, M. Moros, M.Pérez-Hernández, M. Monge, L. Gutiérrez, R. M. Fratila, M. de las Heras, S. Menao Guillén, J. J. Puente Lanzarote, C. Solans, J. Pardo, J. M. de la Fuente - Effect of surface chemistry and associated protein corona on the long-term biodegradation of iron oxide nanoparticles in vivo, ACS Appl. Mater. Interfaces, 2018, 10, 4548
https://pubs.acs.org/doi/10.1021/acsami.7b18648
2017
R. M. Fratila*, M. Navascuez, J. Idiago-López, M. Eceiza, J. I. Miranda, J. M. Aizpurua, J. M. de la Fuente - Covalent immobilisation of magnetic nanoparticles on surfaces via strain-promoted azide–alkyne click chemistry, New J. Chem., 2017, 41, 10835
https://pubs.rsc.org/en/content/articlelanding/2017/NJ/C7NJ01822C#!divAbstract
Y. Hernández, Y. Coello, R. M. Fratila, J. M. de la Fuente, T. A. Lionberger - Highly sensitive ratiometric quantification of cyanide in water with gold nanoparticles via Resonance Rayleigh Scattering, Talanta, 2017, 167, 51
https://www.sciencedirect.com/science/article/pii/S0039914017302102
2016
D. J. Grootendorst, R. M. Fratila, J. Pouw, B. Ten Haken, R. J. A. Van Wezel, S. Rottenberg, W. Steenbergen, S. Manohar, T. J. M. Ruers - Photoacoustic staging of nodal metastases using SPIOs: Comparison between in vivo, in toto and ex vivo imaging in a rat model, Biomedical Spectroscopy and Imaging, 2016, 5, 71
https://content.iospress.com/articles/biomedical-spectroscopy-and-imaging/bsi127
R. M. Fratila, M. Moros, J. M. de la Fuente - Recent advances in biosensing using magnetic glyconanoparticles, Anal Bioanal Chem, 2016, 408,1783
https://link.springer.com/article/10.1007/s00216-015-8953-2
2015
M. V. Gomez, A. M. Rodriguez, A. de la Hoz, F. Jimenez-Marquez, R. M. Fratila, P. A. Barneveld, A. H. Velders - Determination of Kinetic Parameters within a Single Nonisothermal On-Flow Experiment by Nanoliter NMR Spectroscopy, Anal. Chem., 2015, 87, 10547
https://pubs.acs.org/doi/10.1021/acs.analchem.5b02811
R. M. Fratila*, S. Rivera-Fernández, J. M. de la Fuente - Shape matters: synthesis and biomedical applications of high aspect ratio magnetic nanomaterials, Nanoscale, 2015, 7, 8233
https://pubs.rsc.org/en/content/articlelanding/2015/nr/c5nr01100k#!divAbstract
2014
K. S. Wimbush, R. M. Fratila, D. Wang, D. Qi, C, Liang, L. Yuan, N. Yakovlev, K. P. Loh, D. N. Reinhoudt, A. H. Velders, C. A. Nijhuis - Bias induced transition from an ohmic to a nonohmic interface in supramolecular tunneling junctions with Ga2O3/EGaIn top electrodes, Nanoscale, 2014, 6, 11246
https://pubs.rsc.org/en/content/articlelanding/2014/nr/c4nr02933j#!divAbstract
R. M. Fratila, M. V. Gomez, S. Sy´kora, A. H. Velders - Multinuclear nanoliter one-dimensional and two-dimensional NMR spectroscopy with a single non-resonant microcoil, Nat. Commun., 2014, 5:3025 doi: 10.1038/ncomms4025
https://www.nature.com/articles/ncomms4025
J. M. Aizpurua, R. M. Fratila*, Z. Monasterio, N. Pérez-Esnaola, E. Andreieff, A. Irastorza, M. Sagartzazu-Aizpurua - Triazolium cations: from the ‘‘click’’ pool to multipurpose applications, New J. Chem., 2014, 38, 474
https://pubs.rsc.org/en/content/articlelanding/2014/nj/c3nj00667k#!divAbstract
R. M. Fratila, S. G. Mitchell, P. del Pino, V. Grazu, J. M. de la Fuente - Strategies for the Biofunctionalization of Gold and Iron Oxide Nanoparticles, Langmuir, 2014, 30, 15057
https://pubs.acs.org/doi/10.1021/la5015658
2013
A. M. Leferink, R. M. Fratila, Maaike A. Koenrades, C. A. van Blitterswijk, A. Velders, L. Moroni - An Open Source Image Processing Method to Quantitatively Assess Tissue Growth after Non-Invasive Magnetic Resonance Imaging in Human Bone Marrow Stromal Cell Seeded 3D Polymeric Scaffolds, PLoS ONE, 2013, 9, e115000. doi:10.1371/journal.pone.0115000
https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0115000.g003
I. Braceras, J. Oyarbide, P. Azpiroz, N. Briz, E. Ipiñazar, N. Álvarez, G. Atorrasagasti, R. M. Fratila, J. M. Aizpurua - ‘‘Plasma-Click’’ Based Strategy for Obtaining Antibacterial Surfaces on Implants, Plasma Process. Polym., 2013, 10, 328
https://onlinelibrary.wiley.com/doi/abs/10.1002/ppap.201200058
D. J. Grootendorst, R. M. Fratila, M. Visscher, B. Ten Haken, R. J. A. Van Wezel, S. Rottenberg, W. Steenbergen, S. Manohar, T. J. M. Ruers - Intra-operative ex vivo photoacoustic nodal staging in a rat model using a clinical superparamagnetic iron oxide nanoparticle dispersion, J. Biophotonics, 2013, 1–12, DOI 10.1002/jbio.201200204
https://onlinelibrary.wiley.com/doi/abs/10.1002/jbio.201200204
I. Azcune, E. Balentová, M. Sagartzazu-Aizpurua, J. I. Santos, J. I. Miranda, R. M. Fratila*, J. M. Aizpurua - Modulating Lectin Inhibition with N-Glycosyl-1,2,3-triazole Scaffolds, Eur. J. Org. Chem., 2013, 2434
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201201674
D. J. Grootendorst, J. Jose, R. M. Fratila, M. Visscher, A. H. Velders, B. Ten Haken, T. G. Van Leeuwen, W. Steenbergen, S. Manohar, T. J. M. Ruers - Evaluation of superparamagnetic iron oxide nanoparticles (Endorem®) as a photoacoustic contrast agent for intra-operative nodal staging, Contrast Media Mol. Imaging, 2013, 8, 83
https://onlinelibrary.wiley.com/doi/full/10.1002/cmmi.1498
2012
J. M. Aizpurua, M. Sagartzazu-Aizpurua, Z. Monasterio, I. Azcune, C. Mendicute, J. I. Miranda, E. García-Lecina, A. Altube, R. M. Fratila - Introducing Axial Chirality into Mesoionic 4,4'-Bis(1,2,3-triazole) Dicarbenes, Org. Lett., 2012, 14, 1866
https://pubs.acs.org/doi/abs/10.1021/ol3004657
2011
R. M. Fratila*, A. H. Velders - Small-Volume Nuclear Magnetic Resonance Spectroscopy, Annu. Rev. Anal. Chem., 2011, 4, 227
https://www.annualreviews.org/doi/abs/10.1146/annurev-anchem-061010-114024?journalCode=anchem
R. de la Rica, R. M. Fratila, A. Szarpak, J. Huskens, A. H. Velders - Multivalent Nanoparticle Networks as Ultrasensitive Enzyme Sensors, Angew. Chem. Int. Ed., 2011, 50, 5704
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201008189
J. M. Aizpurua, M. Sagartzazu-Aizpurua, I. Azcune, J. I. Miranda, Z. Monasterio, E. García-Lecina, R. M. Fratila - "Click" Synthesis of Nonsymmetrical 4,4′-Bis(1,2,3-triazolium) Salts, Synthesis, 2011, 2737
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0030-1260061
J. M. Aizpurua, J. I. Ganboa, C. Palomo, I. Loinaz, J. Oyarbide, X. Fernandez, E. Balentová, R. M. Fratila, A. Jiménez, J. I. Miranda, A. Laso, S. Ávila, J. L. Castrillo - Cyclic RGD β-Lactam Peptidomimetics Induce Differential Gene Expression in Human Endothelial Cells, ChemBioChem, 2011, 12, 401
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201000572
A. Adamczyk-Wozniak, R. M. Fratila, I. D. Madura, A. Pawełko, A. Sporzynski, M. Tumanowicz, A. H. Velders, J. Zyła - Reactivity of 2-formylphenylboronic acid toward secondary aromatic amines in amination–reduction reactions, Tetrahedron Letters, 2011, 52, 6639
https://www.sciencedirect.com/science/article/pii/S0040403911017163
(31) I. Braceras, P. Azpiroz, N. Briz, R. M. Fratila, J. Oyarbide, E. Ipiñazar, N. Álvarez, G. Atorrasagasti, J. M. Aizpurua - Plasma Polymerized Silylated Ciprofloxacin as an Antibiotic Coating, Plasma Process. Polym., 2011, 8, 599
https://onlinelibrary.wiley.com/doi/abs/10.1002/ppap.201000160
2010
J. M. Aizpurua, C. Palomo, R. M. Fratila, P. Ferrón, J. I. Miranda - Stereomodulating effect of remote groups on the NADH-mimetic reduction of alkyl aroylformates with 1,4-dihydronicotinamide-β-lactam amides, Tetrahedron, 2010, 66, 3187
https://www.sciencedirect.com/science/article/pii/S0040402010003273
J. M. Aizpurua, I. Azcune, R. M. Fratila*, E. Balentová, M. Sagartzazu-Aizpurua, J. I. Miranda - “Click” Synthesis of Nonsymmetrical Bis(1,2,3-triazoles), Org. Lett., 2010, 12, 1584
https://pubs.acs.org/doi/10.1021/ol1003127
2009
J. M. Aizpurua, C. Palomo, R. M. Fratila, P. Ferrón, A. Benito, E. Gómez-Bengoa, J. I. Miranda, J. I. Santos - Mechanistic Insights on the Magnesium(II) Ion-Activated Reduction of Methyl Benzoylformate with Chelated NADH Peptide β-Lactam Models, J. Org. Chem., 2009, 74, 6691
https://pubs.acs.org/doi/10.1021/jo901236d
2007
C. Palomo, J. M. Aizpurua, E. Balentová, A. Jiménez, J. Oyarbide, R. M. Fratila, J. I. Miranda - Synthesis of β-Lactam Scaffolds for Ditopic Peptidomimetics, Org. Lett., 2007, 9, 101
https://pubs.acs.org/doi/10.1021/ol0626241
2006
C. Palomo, J. M. Aizpurua, A. Benito, L. Cuerdo, R. M. Fratila, J. I. Miranda, A. Linden - Functionalization of N-[(Silyl)methyl]-β-lactam Carbanions with Carbon Electrophiles, J. Org. Chem., 2006, 71, 6368
https://pubs.acs.org/doi/10.1021/jo060537g
2004
C. Palomo, J. M. Aizpurua, I. Ganboa, A. Benito, L. Cuerdo, R. M. Fratila, A. Jiménez, I. Loinaz, J. I. Miranda, K. R. Pytlewska, A. Micle, A. Linden, Org. Lett., 2004, 6, 4443
https://pubs.acs.org/doi/10.1021/ol048348c
2003
C. Palomo, J. M. Aizpurua, A. Benito, J. I. Miranda, R. M. Fratila, C. Matute, M. Domercq, F. Gago, S. Martín-Santamaría, A. Linden - Development of a New Family of Conformationally Restricted Peptides as Potent Nucleators of β-Turns. Design, Synthesis, Structure, and Biological Evaluation of a β-Lactam Peptide Analogue of Melanostatin, J. Am. Chem. Soc., 2003, 125, 52, 16243
https://pubs.acs.org/doi/10.1021/ja038180a
Books
Nanomaterials for Magnetic and Optical Hyperthermia Applications, 1st Edition
Editors: Raluca M. Fratila & Jesús Martínez de la Fuente
Paperback ISBN: 9780128139288
eBook ISBN: 9780128139295
Imprint: Elsevier
Published Date: 6th December 2018
Page Count: 384
Book chapters
(1) J. Idiago-López, E. Moreno-Antolín, R. M. Fratila* - Nanomaterials for Combined Thermo-Chemotherapy of Cancer, in "Nanomaterials for Magnetic and Optical Hyperthermia Applications", Ed. Raluca M. Fratila & Jesús Martínez de la Fuente
Elsevier, 2018, chapter 11, pp. 287-314
https://www.sciencedirect.com/science/article/pii/B9780128139288000119
(2) R. M. Fratila*, J. M. de la Fuente - Introduction to Hyperthermia, in "Nanomaterials for Magnetic and Optical Hyperthermia Applications", Ed. Raluca M. Fratila & Jesús Martínez de la Fuente
Elsevier, 2018, chapter 1, pp. 1-10
https://www.sciencedirect.com/science/article/pii/B978012813928809997X
(3) R. M. Fratila*, J. M. de la Fuente - Conclusions: Magnetic and Optical Hyperthermia Using Nanomaterials - Limitations, Challenges and Future Perspectives, in "Nanomaterials for Magnetic and Optical Hyperthermia Applications", Ed. Raluca M. Fratila & Jesús Martínez de la Fuente
Elsevier, 2018, pp. 357-362
https://www.sciencedirect.com/science/article/pii/B9780128139288099993
(4) L. Asín, G. Stepien, M. Moros, R. M. Fratila*, J. M. de la Fuente - Magnetic Nanoparticles for Cancer Treatment Using Magnetic Hyperthermia, in "Clinical Applications of Magnetic Nanoparticles", Ed. N. T. K. Thanh,
CRC Press, 2018, pp. 305-317